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SOX10

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  • SOX10 nuclear staining in clear cell sarcoma of the gastrointestinal tract(redesignated gastrointestinal neuroectodermal tumor(GNET)).
  • Nuclear SOX10 expression in melanoma.
  • Nuclear SOX10 expression in melanoma.
  • Nuclear SOX10 expression in breast myoepithelial cells.


SynonymsEdit

SRY-related HMG-box

AntibodiesEdit

clone 20B7

Technical InfoEdit

Staining PatternEdit

Nuclear and cytoplasmic

Expression in Normal TissuesEdit

This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. In the central nervous system, SOX10 is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.

  • Schwann cells[1]
  • Melanocytes[1]
  • Myoepithelial cells[1]

Expression in Neoplastic EntitiesEdit

  • Clear cell sarcoma of tendons and aponeuroses
  • Gastrointestinal Neuroectodermal Tumor (GNET)
BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Neurofibroma[1]
Schwannoma[1]
Myoepithelioma[1]
Capsular nevi in lymph nodes[1]
Sustentacular cells only of paraganglioma/pheochromocytoma (tumor cells negative)[1]


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Carcinoid tumors (occasionally)[1]


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Desmoplastic melanoma 100%[2] 9/9[2]
Melanoma in-situ 100%[2] 14/14[2]
GNET 100% 15/15
Clear cell sarcoma 100%
Diffuse astrocytoma[1]
Melanoma 97%[1] 76/78[1]
Malignant peripheral nerve sheath tumor (MPNST) 49%[1] 38/77[1]
Metastatic melanoma in lymph nodes[1]
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Dendritic cells in lymph nodes [1]

Practical Uses / PanelsEdit

  • For desmoplastic melanoma, SOX10 is more sensitive than MiTF and more specific than S100 Protein (i.e. - less likely to stain background fibroblasts and histiocytes).[2]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Am J Surg Pathol. 2008 Sep;32(9):1291-8.
  2. 2.0 2.1 2.2 2.3 2.4 Ramos-Herberth FI, Karamchandani J, Kim J, Dadras SS. SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar. J Cutan Pathol. 2010 Sep;37(9):944-52.

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