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Smoothelin

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SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Muscularis propria of bladder (detrusor muscle)[1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following:

  • Muscularis mucosae of bladder[1]
  • Desmoplastic reaction to invasive carcinoma[1]

Practical Uses / PanelsEdit

  • Distinguish true muscularis propria invasion (smoothelin +) from muscularis mucosae invasion or desmoplastic response (smoothelin negative) in invasive urothelial carcinoma.[1]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 1.3 American Journal of Surgical Pathology:June 2010 - Volume 34 - Issue 6 - pp 792-799

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