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  • Nuclear TFE3 expression in alveolar soft part sarcoma.

SynonymsEdit

  • Transcription factor E3

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
*Epithelioid PEComas[1]


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
*Alveolar soft part sarcoma[2]
*Pediatric (Xp11) renal cell carcinoma[2]


Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. Argani P,Aulmann S, Illei P, Netto G, Ro J, Cho H, Dogan S, Ladanyi M, Martignoni G, Goldblum J, Weiss S. A distinctive subset of PEComas harbors TFE3 gene fusions. Am J Surg Pathol. 2010;34:1395-1406
  2. 2.0 2.1 Int J Gynecol Pathol. 2005 Apr;24(2):131-5.

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