• TTF-1 expression in follicular cells of normal thyroid.
  • TTF-1 staining type II pneumocytes in normal lung alveoli.


  • NK2 homeobox 1
  • NKX2-1 (TTF-1 is encoded by gene NKX2-1)


Technical InfoEdit

Staining PatternEdit

  • Nuclear (like all transcription factors)

Expression in Normal TissuesEdit

  • Lung (type II pneumocytes, Clara cells)
  • Thyroid (follicular cells, parafollicular C cells)

Expression in Neoplastic EntitiesEdit

  • Follicular Adenoma of Thyroid

  • Adenocarcinoma of lung origin
  • Small cell carcinoma (of any site, including lung)
  • Most thyroid carcinomas

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Squamous Cell Carcinoma of lung origin

Practical Uses / PanelsEdit

Common PitfallsEdit

Related Links/Other ResourcesEdit


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