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  • Tyrosinase highlights scattered melanin-producing cells in a pigmented neurofibroma.
  • Tyrosinase highlights scattered melanin-producing cells in a pigmented neurofibroma.
Tyrosinase (monophenol monooxygenase)is an enzyme that is responsible for converting tyrosine into melanin in human melanocytes. The tyrosinase gene is regulated by the Microphthalmia-associated transcription factor (MiTF) gene product.[1]

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Melanocytes

Expression in Neoplastic EntitiesEdit

BenignEdit
  • Melanocytic Nevi


IntermediateEdit
MalignantEdit
  • Melanoma

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. Hou L, Panthier JJ, Arnheiter H (2000). "Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF". Development 127 (24): 5379–89. PMID 11076759

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