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  • Wilm's Tumor (99% blastemal) at 10x.
  • Wilm's Tumor (99% blastemal) at 40x.

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

  • Fallopian tube
  • Kidney
  • Mesothelium
  • Ovarian granulosa cells
  • Sertoli cells
  • Spleen

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Endometrial Stromal Tumors 85%[1] 12/14[1]


BenignEdit
  • Metanephric adenoma
  • Nephrogenic rests

Intermediate

  • Nephroblastoma
MalignantEdit
  • Wilm's Tumor
  • Desmoplastic small round cell tumor[2]
  • Mesothelioma
  • Ovarian carcinomas (serous, small cell, and transitional)[3]
  • Rhabdoid tumor
  • Acute myelogenous leukemia

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Endometrial glands (but is expressed in endometrial stroma)
  • Ovarian mucinous and clear cell carcinomas[4]

Practical Uses / PanelsEdit

  • Ovarian carcinoma vs breast or pancreatic carcinoma

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 Int J Gynecol Pathol. 2004 Jul;23(3):241-7.
  2. Carpentieri DF, Nichols K, Chou PM, Mathews M, Pawel B, Huff D. The expression of WT1 in the differentiation of rhabdomyosarcoma from other pediatric small round blue cell tumors. Mod Pathol 2002:15(10):1080-86
  3. O'Neill CJ, Deavers MT, Malpica A, Foster H, McCluggage WG. An immunohistochemical comparison between low-grade and high-grade ovarian serous carcinomas: significantly highre expression of p53, MIB1, BCL2, HER-2/neu, and C-KIT in high grade neoplasms. Am J Surg Pathol. 2005;29(8):1034-41
  4. Waldstrom M, Grove A. Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas. Ach Pathol Lab Med. 2005;129(1):85-8

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