Pathology Resident Wiki
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Synonyms[]

Antibodies[]

Technical Info[]

Staining Pattern[]

  • Nuclear

Expression in Normal Tissues[]

  • Fallopian tube
  • Kidney
  • Mesothelium
  • Ovarian granulosa cells
  • Sertoli cells
  • Spleen

Expression in Neoplastic Entities[]

Benign[]
Tumor name % Positive Staining Number of Cases


Intermediate/Uncertain Malignant Potential[]
Tumor name % Positive Staining Number of Cases


Malignant[]
Tumor name % Positive Staining Number of Cases
Endometrial Stromal Tumors 85%[1] 12/14[1]


Benign[]
  • Metanephric adenoma
  • Nephrogenic rests

Intermediate

  • Nephroblastoma
Malignant[]
  • Wilm's Tumor
  • Desmoplastic small round cell tumor[2]
  • Mesothelioma
  • Ovarian carcinomas (serous, small cell, and transitional)[3]
  • Rhabdoid tumor
  • Acute myelogenous leukemia

Expression in Non-Neoplastic Entities[]

Pertinent Negatives[]

This antigen is typically NOT expressed by the following entities:

  • Endometrial glands (but is expressed in endometrial stroma)
  • Ovarian mucinous and clear cell carcinomas[4]

Practical Uses / Panels[]

  • Ovarian carcinoma vs breast or pancreatic carcinoma

Common Pitfalls[]

Related Links/Other Resources[]

References[]

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