Synonyms[]
Antibodies[]
Technical Info[]
Staining Pattern[]
- Nuclear
Expression in Normal Tissues[]
- Fallopian tube
- Kidney
- Mesothelium
- Ovarian granulosa cells
- Sertoli cells
- Spleen
Expression in Neoplastic Entities[]
Benign[]
Tumor name | % Positive Staining | Number of Cases |
Intermediate/Uncertain Malignant Potential[]
Tumor name | % Positive Staining | Number of Cases |
Malignant[]
Tumor name | % Positive Staining | Number of Cases |
Endometrial Stromal Tumors | 85%[1] | 12/14[1] |
Benign[]
- Metanephric adenoma
- Nephrogenic rests
Intermediate
- Nephroblastoma
Malignant[]
- Wilm's Tumor
- Desmoplastic small round cell tumor[2]
- Mesothelioma
- Ovarian carcinomas (serous, small cell, and transitional)[3]
- Rhabdoid tumor
- Acute myelogenous leukemia
Expression in Non-Neoplastic Entities[]
Pertinent Negatives[]
This antigen is typically NOT expressed by the following entities:
- Endometrial glands (but is expressed in endometrial stroma)
- Ovarian mucinous and clear cell carcinomas[4]
Practical Uses / Panels[]
- Ovarian carcinoma vs breast or pancreatic carcinoma
Common Pitfalls[]
Related Links/Other Resources[]
References[]
- ↑ 1.0 1.1 Int J Gynecol Pathol. 2004 Jul;23(3):241-7.
- ↑ Carpentieri DF, Nichols K, Chou PM, Mathews M, Pawel B, Huff D. The expression of WT1 in the differentiation of rhabdomyosarcoma from other pediatric small round blue cell tumors. Mod Pathol 2002:15(10):1080-86
- ↑ O'Neill CJ, Deavers MT, Malpica A, Foster H, McCluggage WG. An immunohistochemical comparison between low-grade and high-grade ovarian serous carcinomas: significantly highre expression of p53, MIB1, BCL2, HER-2/neu, and C-KIT in high grade neoplasms. Am J Surg Pathol. 2005;29(8):1034-41
- ↑ Waldstrom M, Grove A. Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas. Ach Pathol Lab Med. 2005;129(1):85-8